The Science

Person holding a Peptide Airs oral pouch
The science

Small molecules, placed where they absorb.

Glutathione, NMN and caffeine were picked for one reason. Each is small enough to cross the lining of your cheek instead of fighting your stomach for it.

Backed by research

The route is the whole point.

Swallow an antioxidant and your gut gets first pick. Park it under your lip and the mucosa hands it straight to your bloodstream.

99.9%

purity on our third-party Certificates of Analysis for NMN and glutathione

500 Da

every active sits well inside the size range that crosses the mucosa

25,000+

pouches placed by customers, zero nicotine in any of them

Molecular weights from PubChem. Purity per the Certificates of Analysis shown below. Pouch count is lifetime units sold.

Molecular weight

0 to 600 Da

Permeability drops as molecules get bigger. All three of ours stay small.

CaffeineFocus 194 Da
GlutathioneGlow 307 Da
NMNEnergy 334 Da

The dashed line marks 500 Da. Below it, molecules permeate the oral mucosa readily by passive diffusion. Above it permeability falls off, and true macromolecules need injection or chemical enhancers. Permeability review ↗

What is in the tin

Science in a pouch.

Buccal delivery

Through the cheek, not the gut

Small actives

Sized for the route, not the shelf

Zero nicotine

No tobacco, no sugar, gum safe

Paperwork on file

COAs, GMP, made in the USA

Ingredient by ingredient

Three actives. Three reasons.

Exact amounts are printed on the Supplement Facts panel, which you can open below.

307Da Glow

Glutathione reduced GSH, the master antioxidant

Your cells make glutathione and spend it constantly to mop up oxidative stress. The catch is that swallowed glutathione is largely dismantled before it reaches your blood, which is why the route matters more here than for anything else in the pouch.

The evidence A placebo-controlled crossover trial in 15 healthy adults held 200 mg of glutathione in the mouth for 90 seconds. The orobuccal route raised multiple blood glutathione parameters compared with placebo. Bruggeman et al., PLoS ONE 2019 ↗
334Da Energy

NMN nicotinamide mononucleotide, an NAD+ precursor

NAD+ is the coenzyme sitting in the middle of how your cells turn food into usable energy, and levels fall with age. NAD+ itself is far too large to cross a membrane, so we deliver the precursor and let your cells build the rest.

The evidence In a randomized, double-blind, placebo-controlled trial, 30 healthy adults took 250 mg of NMN daily for 12 weeks. It was well tolerated and significantly raised NAD+ and related metabolites in whole blood. Okabe et al., Front. Nutr. 2022 ↗
194Da Focus

Caffeine anhydrous, the best studied of the three

Caffeine is the smallest active in the pouch and the one with the longest paper trail through the cheek. This is the same principle behind military caffeine gum, and it is why the onset feels quicker than waiting on a coffee to clear your stomach.

The evidence Comparing gum against capsules in healthy volunteers, caffeine peaked in the blood at 44 to 80 minutes with gum versus 84 to 120 minutes with capsules. The authors attributed the speed to buccal absorption. Kamimori et al., Int. J. Pharm. 2002 ↗
Using one

Four steps. No water.

1

Place it

One pouch between your upper lip and gum.

2

Let it sit

A light mint tingle is normal as the pouch softens.

3

Leave it alone

Up to 20 minutes. No chewing, no sipping over it.

4

Bin it

Remove and discard. Pouches do not dissolve.

Read the paperwork yourself

Cool Mint, 16 pouches per can, 4 pouches per day. Everything we test is here in full.

Questions

Answers, with sources.

Why a pouch instead of a capsule?

A capsule has to survive stomach acid and a first pass through your liver before anything reaches your bloodstream. A pouch sits against the inside of your lip, where small molecules pass through the mucosa directly and skip both.

It is the same mechanism behind nicotine lozenges, sublingual B12 and nitroglycerin tablets. Nothing exotic, just a different door.

How much of each active is in a pouch?

All three amounts are printed on the Supplement Facts panel. to see them, and the Certificates of Analysis alongside it show the third-party purity results for NMN and glutathione.

Is there nicotine or tobacco in these?

None. Zero nicotine, zero tobacco and zero tobacco-derived ingredients. They are also sugar free and zero calorie. The pouch format is borrowed from nicotine pouches, the contents are not.

Where are they made and who tests them?

Made in the USA at an FDA registered facility that is Eurofins certified to 21 CFR Part 111 GMP and NSF/ANSI 455-2, both issued March 2026. Actives are tested by an independent third-party lab.

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